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Na superfície dos comprimidos em forma de losango, é permitida a aplicação do logotipo da empresa "ZT" de um
lado e da dosagem "50" ou "100" do outro. Comprimidos revestidos,
de cor azul a azul-clara com tons perlados, de forma
arredondada (doses de vinte e cinco mg, cinquenta mg ou cem mg) ou em forma de
losango (doses de cinquenta mg ou 100 mg), com superfície convexa.
Após a administração oral única de sildenafila em dose de cem mg, a concentração
plasmática máxima média de sildenafila é de por volta de 440 ng/ml (com coeficiente de
variação de 40%). Como a ligação da sildenafila e de teu principal
metabólito N-desmetil ao plasma é de 96%, a concentração plasmática máxima média de sildenafila livre é
de aproximadamente dezoito ng/ml (trinta e oito nM). A biodisponibilidade absoluta média após a
administração oral é de 41% (com variação de 25% a 63%).
Na faixa de doses recomendada (de vinte e cinco a cem mg), os parâmetros AUC e Cmax da sildenafila aumentam proporcionalmente à dose.
A hipotensão sintomática geralmente ocorre dentro de 4 horas após a administração da sildenafila.
A administração concomitante da sildenafila e do
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